Figure 1.

Pattern of fevers. (A) Ten days of representative body temperatures measured orally at approximately 8:00 am, noon, and 8:00 pm are plotted, showing changing amounts of diurnal variation over time. (B) The 8:00 pm temperatures over 300 days are plotted against trials of prednisone and colchicine, as well as onset of menstrual cycles. (C) The median temperatures across 10 menstrual cycles are plotted in relationship to start of menses. (D) The 8:00 am and 8:00 pm temperatures in the 3 months preceding treatment with oral levonorgestrel/ethinyl estradiol are plotted. (E) Temperatures in the 3 months after starting oral levonorgestrel/ethinyl estradiol are plotted. The shaded area indicates the timing of acute otitis media and mastoiditis culminating in mastoidectomy and tympanostomy tube placement. (F) Temperatures are plotted after several months receiving oral levonorgestrel/ethinyl estradiol.