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. 2016 May 12;38(7):674–681. doi: 10.1002/bies.201500175

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2016 The Authors BioEssays Published by WILEY Periodicals, Inc.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Schematic representation of the role of RNP granules/droplets in the segregation of mRNA assemblages. In the nucleus, transcripts are associated with particular RBPs, that – via low‐complexity sequences – drive the formation of liquid droplets containing mRNAs encoding factors participating in a particular biological process or macromolecular complex. Following cellular trafficking to the final destination, the increase in local mRNA concentration facilitates synchronous on‐site protein production.