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. 2016 May 6;87(9):1090–1098. doi: 10.1111/asj.12619

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© 2016 The Authors. Animal Science Journal published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Animal Science

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Chicken glucagon, oxyntomodulin (OXM), glucagon‐like peptide (GLP)‐1 and GLP‐2 are produced in a tissue‐specific manner. Two messenger RNA (RNA) classes, PGA (pancreas) and PGB (brain and gut), are produced by alternate promoter and alternate first exon usage. Translation of these mRNAs produces preproglucagon A or preproglucagon B. In the pancreas, proglucagon A is cleaved by PC1/3 to generate glucagon. In the brain and gut, the proglucagon B is cleaved by PC2 to generate glicentin, OXM, GLP‐1 and GLP‐2.