Figure 5.

DCA nephroprotection is not mediated by reduced renal CP levels or by transcriptional changes in CP transporters. Mice were treated with sal, DCA, CP, or CP and DCA, as outlined in the CP-induced AKI model section in the Concise Methods. (A) Renal platinum levels were measured in the kidneys of mice by ICP‑MS 2 and 24 hours after CP administration. Results are expressed as mean±SEM, n=8 animals per group. Transcript levels of (B) OCT2/SLC22A2, (C) CTR1/SLC31A1, (D) ATP7A, (E) ATP7B, and (F) MATE1/SLC49A1 in the kidneys, derived from transcriptome data (Supplemental Table 1), expressed as transcripts per million, from kidneys of mice treated with sal, DCA, CP, or CP and DCA, 24 hours after CP administration. Results are expressed as mean±SEM, n=3 animals per group. ***P<0.001; **P<0.01. NS, not significant.