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Alloantibody induced by donor-reactive memory CD4 T cells facilitate vascular injury and platelet aggregation within renal allografts. Renal allografts were harvested at indicated time points after transplantation. Immunohistology for C4d and vWf was scored in a blinded fashion as outlined in Concise Methods. AMR was assessed on evidence of (A) vascular injury and (B) platelet aggregation. aCD8, anti-CD8 antibody; end mem, endogenous memory; sens mem, sensitized memory.
