Table 1.
Baseline characteristics of the clinical trial populations
| BENEDICT, n=742 | DIRECT (T1D), n=3093 | DIRECT (T2D), n=1758 | ALTITUDE, n=3654 | IRMA-2 Trial, n=565 | |
|---|---|---|---|---|---|
| Men, n (%) | 397 (53.5) | 1771 (57.3) | 858 (48.1) | 2497 (68.3) | 391 (69.2) |
| Age, yr, n (%) | 61.9 (8.0) | 31.0 (8.4) | 56.9 (7.7) | 65.8 (9.4) | 58.1 (8.6) |
| Diastolic BP, mmHg, n (%) | 88.8 (7.7) | 73.1 (6.9) | 78.0 (7.0) | 74.1 (10.0) | 89.6 (9.3) |
| Systolic BP, mmHg, n (%) | 152.4 (14.0) | 116.9 (9.6) | 132.7 (13.5) | 138.2 (16.3) | 152.7 (14.6) |
| Albuminuriaa | 5.2 [3.5–8.8]b | 4.5 [3.5–7.0]b | 5 [3.5–8.0]b | 23.7 [4.11–73.6]c | 58.0 [33.0–102.0]c |
| Normoalbuminuria, n (%) | 742 (100) | 3093 (100) | 1758 (100) | 1020 (27.9) | 0 (0) |
| Microalbuminuria, n (%) | 0 (0) | 0 (0) | 0 (0) | 2634 (72.1) | 565 (100) |
| Hemoglobin A1c, n (%) | 3.0 (1.4) | 8.3 (1.6) | 8.2 (1.6) | 7.9 (1.7) | 7.0 (1.7) |
| Total cholesterol, mg/dl, n (%) | 211.8 (36.5) | 184.8 (37.5) | 204.9 (42.5) | 170.5 (46.4) | 223.2 (44.4) |
| eGFR, ml/min per 1.73 m2, n (%) | 81.4 (15.3) | 80.8 (13.7) | 70.0 (14.2) | 55.4 (20.6) | 70.5 (12.4) |
T1D, type 1 diabetes; T2D, type 2 diabetes.
a
Presented as median and interquartile range.
b
Urinary albumin excretion rate: micrograms per minute.
c
UACR: milligrams per gram.