Table 4.
Cox proportional hazard analysis for PAG and free p-cresyl sulfate
| Model | PAG (Ln) | Free p-Cresyl Sulfate (Ln) | ||
|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | |
| Mortality | ||||
| Unadjusted | 2.17 (1.57 to 2.99) | <0.001 | 2.23 (1.57 to 3.15) | <0.001 |
| Full model | 1.77 (1.22 to 2.57) | 0.003 | 1.30 (0.81 to 2.07) | 0.28 |
| Cardiovascular disease | ||||
| Unadjusted | 2.21 (1.70 to 2.87) | <0.001 | 2.25 (1.69 to 2.98) | <0.001 |
| Full model | 1.79 (1.32 to 2.41) | <0.001 | 1.58 (1.15 to 2.17) | 0.005 |
Full model with adjustment for age, sex, diabetes mellitus, prior cardiovascular disease, and eGFR (Ln). HR is presented per 1-SD increase (95% CI). Ln, natural logarithmic transformation.