Table 2.
Risk of AKI following cardiac surgery based on HMOX1 genotype
| Event Rates, n (%) | Unadjusted | Adjusted | ||||||
|---|---|---|---|---|---|---|---|---|
| End Point | All (n=2377) | SS (n=304) | SL (n=1102) | LL (n=971) | Odds Ratioa (95% CI) | P Value | Odds Ratioa (95% CI) | P Value |
| Primary end point | ||||||||
| AKI | 347 (14.6) | 34 (11.2) | 152 (13.8) | 161 (16.6) | 1.25 (1.05 to 1.49) | 0.01 | 1.26 (1.05 to 1.50) | 0.01 |
| Secondary end points | ||||||||
| Increase in SCr ≥25% in 5 d or RRT | 492 (20.7) | 51 (16.8) | 222 (20.2) | 219 (22.6) | 1.19 (1.02 to 1.38) | 0.03 | 1.18 (1.02 to 1.38) | 0.03 |
| Increase in SCr ≥50% in 5 d or RRT | 171 (7.2) | 19 (6.3) | 72 (6.5) | 80 (8.2) | 1.20 (0.95 to 1.52) | 0.13 | 1.20 (0.94 to 1.53) | 0.14 |
| Increase in SCr ≥100% in 5 d or RRT | 48 (2.0) | 5 (1.6) | 21 (1.9) | 22 (2.3) | 1.18 (0.77 to 1.83) | 0.45 | 1.20 (0.76 to 1.89) | 0.43 |
AKI was defined as an absolute increase in SCr ≥0.3 mg/dl above baseline within the first 48 hours following cardiac surgery, a relative increase in SCr ≥50% above baseline within 5 days following cardiac surgery, or postoperative need for RRT.13
a
Additive genetic models for each L allele. Adjusted models include age, gender, preoperative eGFR, diabetes mellitus, hypertension, prior cardiac surgery, type of procedure (CABG alone, valve alone, or CABG/valve combined), CPB time, number of intraoperative pRBC transfusions, urgent procedure, and institution.