Figure 2:

Psychomotor vigilance Task. A, Repeated-measures analysis of variance (ANOVA) results of the attention phase of the psychomotor vigilance task superimposed to a standard brain template (colors indicate P values of significant voxels, cluster-based P < .05; cluster size, K ≥ 10) shows positive drug × time interactions in favor of a methylene blue effect in the bilateral anterior and posterior insular cortices (n = 26, with 24 degrees of freedom). B, Representative block from the psychomotor vigilance task shows the stimulus, attention, reaction, feedback, and rest phases as demarcated by set times.