Skip to main content
. 2016 Oct 28;11(10):e0165360. doi: 10.1371/journal.pone.0165360

Fig 6. Histological features of hepatoprotective effect of liver fibrosis to cytotoxic agents.

Fig 6

HPS-stained liver slices of Foxn1 nu/nu mice injected with the following cytotoxic agents: CCl4 [0.5 mL/kg bw] in (A) non-fibrotic and (B) fibrotic mice (16 weeks of TAA in drinking water [0.02%] (sacrificed 24 hours following TAA treatment); Fas Jo2 antibody [0.5 μg/g bw] in (C) non-fibrotic and (D) fibrotic mice (sacrificed 6 hours following TAA treatment); and APAP [750 mg/kg bw] in (E) non-fibrotic and (F) fibrotic mice (sacrificed 6 hours following TAA treatment). Representative microphotographs were obtained at a 100X magnification. Arrows indicate parenchymal red blood cell infiltration and/or necrosis.