Fig 1. Incidence rates and adjusted hazard ratios for 1-year clinical outcomes according to proportion of time in therapeutic range.

Reference group: TTR≥65%. Incidence rates are per 100 person-years. CI, confidence interval; HR, hazard ratio; SE, systemic embolism; TTR, time in therapeutic range. HRs were controlled for the following potential confounders: age group (≤64, 65–69, 70–74, ≥75 years), gender, smoking (no, ex, current), congestive heart failure, vascular disease, moderate-to-severe chronic kidney disease, diabetes mellitus, hypertension, previous stroke (not included in the model for major bleeding events), previous bleeding (not included in the model for stroke/SE), antiplatelet treatment, type of atrial fibrillation, and area (Europe, Asia, other countries).