Table 1. Baseline characteristics of patients according to proportion of time in therapeutic range.
| TTR<65% (N = 5851; 58.9%) | TTR≥65% (N = 4083; 41.1%) | Total (N = 9934; 100%) | ||||
|---|---|---|---|---|---|---|
| Age, mean (SD), years | 70.7 (10.6) | 71.9 (9.7) | 71.2 (10.2) | |||
| Age group, n/N, % | ||||||
| 65–74 years | 2029/5851 | 34.7 | 1430/4083 | 35.0 | 3459/9934 | 34.8 |
| ≥75 years | 2343/5851 | 40.0 | 1786/4083 | 43.7 | 4129/9934 | 41.6 |
| Women, n/N, % | 2649/5851 | 45.3 | 1791/4083 | 43.9 | 4440/9934 | 44.7 |
| BMI category, n/N, % | ||||||
| <19 kg/m2 | 109/4594 | 2.4 | 40/3137 | 1.3 | 149/7731 | 1.9 |
| 19–<25 kg/m2 | 1390/4594 | 30.3 | 771/3137 | 24.6 | 2161/7731 | 28.0 |
| 25–<30 kg/m2 | 1715/4594 | 37.3 | 1245/3137 | 39.7 | 2960/7731 | 38.3 |
| 30–<40 kg/m2 | 1214/4594 | 26.4 | 973/3137 | 31.0 | 2187/7731 | 28.3 |
| ≥40 kg/m2 | 166/4594 | 3.6 | 108/3137 | 3.4 | 274/7731 | 3.5 |
| Medical history, n/N, % | ||||||
| Congestive heart failure | 1189/5851 | 20.3 | 673/4083 | 16.5 | 1862/9934 | 18.7 |
| History of hypertension | 4574/5842 | 78.3 | 3283/4073 | 80.6 | 7857/9915 | 79.2 |
| Diabetes mellitus | 1490/5851 | 25.5 | 888/4083 | 21.7 | 2378/9934 | 23.9 |
| Prior stroke/transient ischaemic attack | 751/5851 | 12.8 | 583/4083 | 14.3 | 1334/9934 | 13.4 |
| Vascular disease* | 814/5842 | 13.9 | 608/4077 | 14.9 | 1422/9919 | 14.3 |
| Chronic kidney disease (Grade ≥3)† | 749/5851 | 12.8 | 522/4083 | 12.8 | 1271/9934 | 12.8 |
| History of bleeding | 121/5838 | 2.1 | 70/4077 | 1.7 | 191/9915 | 1.9 |
| Alcohol consumption, n/N, % | ||||||
| Abstinent | 2585/4943 | 52.3 | 1544/3346 | 46.1 | 4129/8289 | 49.8 |
| Light | 1701/4943 | 34.4 | 1427/3346 | 42.6 | 3128/8289 | 37.7 |
| Moderate | 521/4943 | 10.5 | 323/3346 | 9.7 | 844/8289 | 10.2 |
| Heavy | 136/4943 | 2.8 | 52/3346 | 1.6 | 188/8289 | 2.3 |
| Smoker, n/N, % | ||||||
| No | 3329/5277 | 63.1 | 2332/3671 | 63.5 | 5661/8948 | 63.3 |
| Ex-smoker | 1411/5277 | 26.7 | 1055/3671 | 28.7 | 2466/8948 | 27.6 |
| Current smoker | 537/5277 | 10.2 | 284/3671 | 7.7 | 821/8948 | 9.2 |
*Peripheral artery disease or coronary artery disease with a history of acute coronary syndromes.
†Renal function was assessed according to the National Kidney Foundation’s Kidney Disease Outcomes Quality Initiative classification by investigators at baseline.
BMI, body mass index; SD, standard deviation; TTR, time in therapeutic range.