Table 6. Four-month event rates in patients with proportion of time in therapeutic range <65% and ≥65%.
| TTR<65% | TTR≥65% | Total | |||||
|---|---|---|---|---|---|---|---|
| Events | Rate, per 100 person-years (95% CI) | Events | Rate, per 100 person-years (95% CI) | Events | Rate, per 100 person-years (95% CI) | ||
| Stroke/SE | 1st to 4th months | 36 | 1.88 (1.35 to 2.60) | 8 | 0.59 (0.30 to 1.19) | 44 | 1.35 (1.00 to 1.81) |
| 5th to 8th months | 29 | 1.54 (1.07 to 2.22) | 10 | 0.75 (0.40 to 1.39) | 39 | 1.21 (0.89 to 1.66) | |
| 9th to 12th months | 17 | 0.94 (0.59 to 1.52) | 8 | 0.61 (0.31 to 1.22) | 25 | 0.80 (0.54 to 1.19) | |
| Total | 82 | 1.46 (1.18 to 1.82) | 26 | 0.65 (0.44 to 0.96) | 108 | 1.13 (0.93 to 1.36) | |
| Major bleeding | 1st to 4th months | 39 | 2.03 (1.49 to 2.78) | 11 | 0.82 (0.45 to 1.48) | 50 | 1.53 (1.16 to 2.02) |
| 5th to 8th months | 30 | 1.60 (1.12 to 2.28) | 4 | 0.30 (0.11 to 0.80) | 34 | 1.06 (0.76 to 1.48) | |
| 9th to 12th months | 16 | 0.89 (0.54 to 1.45) | 22 | 1.68 (1.11 to 2.56) | 38 | 1.22 (0.89 to 1.68) | |
| Total | 85 | 1.52 (1.23 to 1.88) | 37 | 0.93 (0.67 to 1.28) | 122 | 1.27 (1.07 to 1.52) | |
| All-cause mortality | 1st to 4th months | 74 | 3.84 (3.06 to 4.83) | 22 | 1.63 (1.07 to 2.47) | 96 | 2.93 (2.40 to 3.58) |
| 5th to 8th months | 89 | 4.70 (3.82 to 5.78) | 29 | 2.16 (1.50 to 3.11) | 118 | 3.64 (3.04 to 4.36) | |
| 9th to 12th months | 96 | 5.27 (4.31 to 6.43) | 38 | 2.89 (2.11 to 3.97) | 134 | 4.27 (3.61 to 5.06) | |
| Total | 259 | 4.59 (4.06 to 5.18) | 89 | 2.22 (1.80 to 2.73) | 348 | 3.61 (3.25 to 4.01) | |
CI, confidence interval; SE, systemic embolism; TTR, time in therapeutic range.