Figure 3. Region of the KCNH2 (LQTS2) mutation predicted seizures.

(A) Percent of LQTS2 participants with mutations in each topological region with seizures vs sum of all other regions (χ²: ratio of seizure cohort—total with mutations in that region). (B) Multivariate analysis indicated that the pore and cNBD regions were independent predictors of seizures. C-term = C-terminus; cNBD = cyclic nucleotide binding domain; N-term = N-terminus; LQTS = long QT syndrome; QT_c = corrected QT interval; Trans = transmembrane.