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. 2016 Oct 28;11(10):e0164042. doi: 10.1371/journal.pone.0164042

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© 2016 Urban et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 9 — Frames taken from time-lapse TIRF-SIM videos of n = 3 representative Lifeact-GFP mouse platelets from either Pdlim7^-/- or WT genetic backgrounds spreading on glass (see S1 and S2 videos). WT platelets (top row) showing the dynamic nature of actin cytoskeleton formation. Pdlim7^-/- platelets (bottom row) demonstrating a dramatically altered spatiotemporal-resolved organization of the F-actin, resulting in a significantly deformed cytoskeletal shape. Arrows indicate areas of dynamic polymerization of F-actin filaments. After 3 to 4 minutes of illumination photobleaching becomes apparent; loss of fluorescence intensity was compensated for by adjusting exposure to +3 using Photoshop software for Pdlim7^-/- platelets. Time stamp = mins. Scale bar = 5 μm.