Table 2. Pathways Associated with Apoptosis.

Pathway	Wiki-Pathway Reference	P Value	Number of regulated genes	Number of genes in pathway
Apoptosis	WP254 78808	0.021	17	84
FAS pathway and Stress induction of HSP regulation	WP314 71366	0.033	9	38
Apoptotic execution phase	WP1784 76813	0.033	10	46

Statistically significant pathways associated with apoptosis for genes expressed over the 25 day time-course of A549 differentiation in Ham’s F12 medium. Pathways were identified using Genespring pathway analysis after one way ANOVA of all of the time points compared to log-phase A549 cells (P cut off = 0.05, Fold change ≥ 2.0).