Fig 3. Correlation of the DM value with IC50 for different molecules that bind MDM2: compound 14-b [22], nutlin-3a [20], compound 1-a [23] and compound DING-1a [24], whose IC-50 are 9.2, 90, 1230 and 8400 nM, respectively.

We also include the values of binding energy calculated by the MM-PBSA and MM-GBSA methods.