Table 1. Combined treatment with ABT263 and L-asparaginase (Asp) results in a synergistic anti-proliferative effect in SF188, LN229 and NCH644 glioblastoma cells.
| SF188 | LN229 | NCH644 | ||||||
|---|---|---|---|---|---|---|---|---|
| Asp (IU/ml) | ABT263 (μM) | CI | Asp (IU/ml) | ABT263 (μM) | CI | Asp (IU/ml) | ABT263 (μM) | CI |
| 20.0 | 0.125 | 0.37373 | 10.0 | 0.125 | 0.55783 | 20.0 | 0.93 | 0.17568 |
| 20.0 | 2.0 | 0.10444 | 10.0 | 2.0 | 0.04420 | 20.0 | 15.0 | 0.28107 |
| 10.0 | 0.25 | 0.16943 | 5.0 | 0.25 | 0.25976 | 10.0 | 1.87 | 0.39124 |
| 10.0 | 1.0 | 0.10173 | 5.0 | 1.0 | 0.12358 | 10.0 | 7.5 | 0.38818 |
| 5.0 | 0.5 | 0.12043 | 2.5 | 0.5 | 0.14549 | 5.0 | 3.75 | 0.51880 |
| 2.5 | 1.0 | 0.25964 | 1.25 | 0.25 | 0.25930 | 2.5 | 7.5 | 0.53591 |
| 2.5 | 0.25 | 0.38731 | 1.25 | 1.0 | 0.18630 | 2.5 | 1.87 | 0.46571 |
| 1.25 | 2.0 | 0.56838 | 0.6125 | 0.125 | 0.45275 | 1.25 | 15.0 | 0.25492 |
| 1.25 | 0.125 | 0.77678 | 0.6125 | 2.0 | 0.32081 | 1.25 | 0.93 | 0.35660 |
The CompuSyn software (ComboSyn, Inc., Paramus, NJ, U.S.A.) was used for the drug-drug interaction analysis including the calculation of the combination index (CI). A CI < 1 was considered as synergistic, a CI = 1 as additive and a CI>1 as antagonistic.