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. 2016 May 27;7(23):33557–33570. doi: 10.18632/oncotarget.9677

Figure 3. β2SP depletion impairs IR-induced repairsomes formation.

Figure 3

A. Sptbn1−/− and Sptbn1+/+ MEFs were irradiated with 2 Gy then examined for γ-H2AX foci formation at different time points post irradiation. B. Sptbn1−/− and Sptbn1+/+ MEFs were irradiated with 4 Gy examined for 53BP1 foci at different time points post irradiation. C. Quantification of human cells with 53BP1 foci, with and without β2SP depletion, 4 hour after exposure to 5 Gy. D. Quantification of human cells with RIFI foci, with and without β2SP depletion 4 hour after exposure to 5 Gy. E. Colocalization of RIF1 and 53BP1 foci in human cells with and without β2SP depletion. F. Quantification of colocalization of RIF1 and 53BP1 foci. G. Error bars represent standard deviations, 3 independent experiments were performed. *p < 0.05 and *p < 0.01 Student t-test.