Figure 2. TH-302 treatment reduces tumor weight and growth rate in fast-growing hypoxic xenografts.

A. Treatment schedule for chronic TH-302 treatment of subcutaneous tumors. Animals were treated with 50mg/kg TH-302 on days 1, 5 and 9 and 2Gy of irradiation on days 2, 3 and 4. B. Tumor growth of OCIP19 (n = 6 per group), OCIP23 (n = 6 per group), OCIP51 (n = 6 per group), OCIP83 (n = 4 per group) and OCIP110 (n = 4 per group) in response to treatment with TH-302 or IR alone or with the combination of both according to the treatment schedule. Tumor volume was measured using calipers and referenced back to the starting volume to calculate the change in tumor volume over the course of the treatment. Error bars represent SEM. * p≤0.05; ** p≤ 0.01