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. 2016 May 29;7(23):33571–33580. doi: 10.18632/oncotarget.9654

Figure 3. TIC frequency strongly correlates with tumor growth rate but not hypoxia.

Figure 3

A. Statistical analysis shows that TIC frequency strongly correlates with tumor growth (R = 0.88), B. but not with the magnitude of tumor hypoxia (R = 0.4). The apparent rapid growth seen in OCIP130, which had the lowest TIC frequency, is explained by the accumulation of mucin-filled ducts resulting in a tumor mass disproportionate to the cellular content (Supplementary Figure 2E). C. Treatment with 10Gy of IR reduced the TIC frequency in most of the tested models. TH-302 as a single agent reduced TIC in a dose dependent manner in most of the tested models with the exception of OCIP23. A similar dose-dependency is observed in the TH-302 + IR group. With the exception of OCIP19, the combination of TH-302 and IR was beneficial compared to IR or TH-302 alone in all tested models.