Table 2. Effects of TH-302 and ionizing radiation on TIC frequency.
Frequency | lower Frequency | upper Frequency | ||
---|---|---|---|---|
OCIP19 | ||||
control | 1:1,386 | 1:2,263 | 1:849 | |
IR | 1:18,932 | 1:35,427 | 1:10,117 | |
TH-302 50mg | 1:162 | 1:473 | 1:56 | |
TH-302 150mg | 1:1,639 | 1:3,600 | 1:746 | |
TH-302+IR 50mg | 1:4,463 | 1:9,860 | 1:2,020 | |
TH-302+IR 150mg | 1:32,225 | 1:57,178 | 1:18,162 | |
OCIP23 | ||||
control | 1:46 | 1:67 | 1:31 | |
IR | 1:266 | 1:431 | 1:164 | |
TH-302 50mg | 1:107 | 1:287 | 1:40 | |
TH-302 150mg | 1:121 | 1:311 | 1:44 | |
TH-302+IR 50mg | 1:2,211 | 1:4,520 | 1:1,082 | |
TH-302+IR 150mg | 1:18,324 | 1:38,188 | 1:8,793 | |
OCIP51 | ||||
control | 1:8 | 1:11 | 1:7 | |
IR | 1:2,014 | 1:3,368 | 1:1,204 | |
TH-302 50mg | 1:80 | 1:131 | 1:49 | |
TH-302 150mg | 1:1,743 | 1:3,160 | 1:962 | |
TH-302+IR 50mg | 1:9,873 | 1:17,236 | 1:5,655 | |
TH-302+IR 150mg | 1:7,581,431 | 1:17,535,190 | 1:3,277,872 | |
OCIP83 | ||||
control | 1:1,579 | 1:3,299 | 1:756 | |
IR | 1:12,748 | 1:26,702 | 1:6,086 | |
TH-302 50mg | 1:810 | 1:1,589 | 1:413 | |
TH-302 150mg | 1:9,488 | 1:24,719 | 1:3,642 | |
TH-302+IR 50mg | 1:45,903 | 1:85,665 | 1:24,597 | |
TH-302+IR 150mg | 1:845,975 | 1:526,700 | 1:2,141,477 |