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. 2016 May 9;7(23):33581–33594. doi: 10.18632/oncotarget.9254

Figure 4. Impact of NP mAb transfer on influenza infection.

Figure 4

Young (2-3 mos.) and aged (19-22 mos.) C57BL/6 mice were administered anti-NP mAb or isotype control mAb (350 ug i.p.) on days -1 and day 0. On day 0, they were infected intranasally with 400 EID50 of PR8 influenza. A. Weight loss and B. survival were monitored following infection. C. On 5 dpi infection, mRNA was prepared from lung tissue from young and aged mice to quantitate influenza PA by real-time PCR. D. BAL was also harvested from young and aged mice on day 5 and cytokine and chemokine levels were determined by multiplex assay. *p < 0.05 by Student's t test comparing vaccinated and control groups; **p < 0.05 by Log rank test.