Table 2. Allelic association of SNPs of NPR-C with coronary artery disease in Rep-Shandong, Rep-Hubei, Re-Sichuan and Re-Shaanxi cohorts.
| SNP_ID | Minor Allele | Re-Shandong | Re-Hubei | Re-Sichuani | Re-Shaanxi | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MAF(%)* | OR(95%CI) † | P-obs ‡ | MAF(%)* | OR(95%CI) † | P-obs ‡ | MAF(%)* | OR(95%CI) † | P-obs ‡ | MAF(%)* | OR(95%CI) † | P-obs ‡ | ||||||
| Case | Control | Case | Control | Case | Control | Case | Control | ||||||||||
| rs700926 | G | 23.6 | 19.4 | 1.34(1.07-1.52) | 3.2E-4 | 26.0 | 19.1 | 1.42(1.17-1.59) | 5.4E-5 | 24.1 | 19.6 | 1.40(1.08-1.51) | 1.4E-5 | 26.3 | 21.4 | 1.25(0.95-1.44) | 2.2E-4 |
| rs1833529 | G | 22.2 | 19.3 | 1.30(1.15-1.48) | 1.5E-4 | 23.4 | 17.9 | 1.35(1.09-1.57) | 1.5E-5 | 21.0 | 15.0 | 1.45(1.05-163) | 2.9E-5 | 23.7 | 17.5 | 1.38(1.01-1.45) | 8.5E-4 |
| rs2270915 | G | 20.1 | 14.9 | 1.43(1.12-1.83) | 3.8E-3 | 20.9 | 17.6 | 1.23(1.10-152) | 0.05 | 21.0 | 15.0 | 1.51(1.10-1.73) | 1.7E-3- | 21.5 | 16.8 | 1.38(1.10-1.78) | 5.1E-4 |
| rs17541471 | C | 17.2 | 14.0 | 1.29(1.05-1.61) | 0.02 | 17.5 | 13.4 | 1.31(1.08-1.69) | 0.01 | 17.0 | 13.0 | 1.30(1.03-1.61) | 0.07 | 18.0 | 13.2 | 1.40(1.05-1.65) | 0.01 |
| rs3792758 | T | 17.1 | 13.1 | 1.32(1.10-1.61) | 3.0E-3 | 18.4 | 12.8 | 1.54(1.20-1.99) | 7.7E-4 | 17.0 | 12.5 | 1.61(1.10-1.82) | 5.1E-3 | 17.5 | 13.0 | 1.43(1.10-1.75) | 1.0E-3 |
| rs696831 | T | 19.1 | 15.4 | 1.38(1.12-1.75) | 0.02 | 17.3 | 13.7 | 1.32(1.02-1.70) | 0.03 | 18.3 | 15.0 | 1.40(1.06-1.70) | 0.01 | 18.1 | 13.4 | 1.37(1.12-1.75) | 0.04 |
| rs7715279 | A | 12.1 | 11.2 | 1.20(0.93-1.30) | 0.49 | 11. 7 | 9.6 | 1.25(0.94-1.65) | 0.12 | 11.2 | 10.0 | 1.23(0.95-1.37) | 0.13 | 12.8 | 12.6 | 0.98(0.69-1.40) | 0.93 |
| rs6450922 | G | 25.4 | 24.5 | 1.25(1.02-1.25) | 0.65 | 26.1 | 25.5 | 1.29(1.00-1.67) | 0.05 | 25.3 | 24.9 | 1.20(1.00-1.20) | 0.98 | 251 | 24.6 | 1.18(0.95-1.20) | 0.84 |
| rs10941022 | T | 13.6 | 14.5 | 0.92(0.71-1.21) | 0.57 | 12.7 | 11.6 | 1.11(0.90-1.37) | 0.34 | 14.6 | 13.9 | 1.10(0.98-1.27) | 0.81 | 14.1 | 13.6 | 1.01(0.98-1.28) | 0.71 |
| rs976576 | G | 29.2 | 27.0 | 1.00(0.85-1.14) | 0.21 | 28.5 | 27.0 | 1.05(0.95-1.15) | 0.54 | 28.0 | 27.5 | 1.02(0.79-1.10) | 0.69 | 29.3 | 27.1 | 1.12(0.98-1.21) | 0.32 |
*
MAF: minor allele frequency.
†
OR, odds ratio. CI, confidence interval.
‡
P-obs, uncorrected P value.