Table 1. Body and Brain weights of rat pups from study groups.

Groups		Body	Weight (g)	Brain	P
		P7	P14	weight (g)
Pretreatment
Sham		12.04±0.52	26.96±0.73	1.20±0.01
Vehicle		12.52±0.41	27.86±0.65	1.15±0.01
5mg/kg E4		15.03±0.68	24.61±1.19	1.18±0.03
5mg/kg E4+1.6mg/kg P4		12.89±0.46	26.63±1.30	1.21±0.03
5mg/kg E4+1.6mg/kg P4+136ng/kg E2		11.93±0.36	22.04±0.66	1.19±0.03
5mg/kg E4+16mg/kg P4		15.94±0.29	25.58±1.47	1.17±0.02	*
5mg/kg E4+16mg/kg P4+136ng/kg E2		14.27±0.70	21.55±0.68	1.16±0.03
5mg/kg E4+136ng/kg E2		11.94±0.59	23.91±1.34	1.12±0.03
10mg/kg E4		13.35±0.47	27.10±0.83	1.19±0.02
10mg/kg E4+1.6mg/kg P4		12.83±0.66	25.57±0.99	1.25±0.01
10mg/kg E4+1.6mg/kg P4+136ng/kg E2		13.59±0.50	27.91±1.18	1.23±0.02
10mg/kg E4+16mg/kg P4		13.55±0.34	26.46±1.20	1.23±0.03
10mg/kg E4+16mg/kg P4+136ng/kg E2		13.15±0.25	27.99±1.03	1.24±0.01
10mg/kg E4+136ng/kg E2		12.47±0.52	25.69±0.93	1.21±0.03
Treatment
Sham		12.04±0.52	26.96±0.73	1.20±0.01
Vehicle		13.43±0.35	26.63±0.71	1.17±0.02
5mg/kg E4		14.14±0.62	28.21±1.23	1.28±0.01
5mg/kg E4+1.6mg/kg P4		14.08±0.65	27.16±0.66	1.23±0.02
5mg/kg E4+1.6mg/kg P4+136ng/kg E2		13.66±0.43	25.67±0.88	1.29±0.01
5mg/kg E4+16mg/kg P4		13.51±0.41	27.11±1.18	1.26±0.03
5mg/kg E4+16mg/kg P4+136ng/kg E2		15.03±0.49	28.13±1.37	1.22±0.03
5mg/kg E4+136ng/kg E2		13.93±0.37	24.43±2.07	1.15±0.05
10mg/kg E4		14.25±0.59	30.82±0.54	1.34±0.01	**
10mg/kg E4+1.6mg/kg P4		13.83±0.66	24.97±0.89	1.20±0.02
10mg/kg E4+1.6mg/kg P4+136ng/kg E2		13.44±0.47	25.48±1.22	1.25±0.02
10mg/kg E4+16mg/kg P4		13.93±0.39	25.98±0.74	1.32±0.01
10mg/kg E4+16mg/kg P4+136ng/kg E2		14.17±0.51	32.41±0.96	1.26±0.02
10mg/kg E4+136ng/kg E2		15.04±0.42	28.64±2.76	1.22±0.04

Significant differences were observed:

^*Body weight at P7- 5mg/kg/d E4+16mg/kg/d P4 group vs. sham, vehicle and 5mg/kg/d E4+136ng/kg/d E2 in pretreated groups;

^**Brain weight- 10mg/kg/d E4 vs. vehicle in treated groups.