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. 2016 Mar 17;7(23):33744–33764. doi: 10.18632/oncotarget.8164

Figure 7. Overexpression of miR-155 restored DKO CD8 T cell responses.

Figure 7

a.-b. Expression of miR-155 a. and Id3 b. in donor-derived OT1 effector or memory cells sorted from splenocytes of recipients on day 7 or 35 after LM-OVA infection. Data shown (mean ± SEM) are calculated from triplicate and represent three experiments. c.-d. Splenocytes from WT or DKO OT1 mice were spin-infected with indicated retrovirus after SIINFEKL stimulation for 40 hours. Infected GFP+ OT1 T cells were adoptively transferred into recipients, followed by infection with LM-OVA. Representative dot plots of WT or DKO donor-derived OT1 cells in PBLs of recipients on day 7 c. and day 35 d. postinfection are shown. e. Percentage of donor-derived OT1 cells among PBLs at indicated times postinfection. f. Percentage of donor OT1 cells in splenocytes on day 35 postinfection. *, P < 0.05; **, P < 0.01; ***, P < 0.001 (Student's t test). Data in c.-f. represent two experiments.