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. 2016 Mar 31;7(23):34011–34021. doi: 10.18632/oncotarget.8514

Figure 4. CDK4 is upregulated in NSCLC tissues and cell lines.

Figure 4

A. The relative expression of CDK4 mRNA from qRT-PCR of corresponding non-tumor tissues (NT) and tumor tissues (T). 18S was used for normalization. B. The relative expression of CDK4 mRNA in stage I/II tumors and stage III/IV tumors. C. The relative expression of CDK4 mRNA in adenocarcinoma (Ad) and squamous cell carcinoma (Sq). D. The relative expression of CDK4 mRNA in lung cancer cell lines or a pulmonary epithelial cell line (control) was measured by qRT-PCR. * P<0.05, ** P<0.01, *** P<0.001. E. MiR-486-5p had a negative correlation with CDK4 according to Pearson Correlation Coefficient. F. The effect of CDK4 expression levels on the overall survival in 1926 lung cancer patients was analyzed and Kaplan-Meier plots were generated using a Kaplan-Meier Plotter (http://www.kmplot.com).