Figure 7. Tissue distribution of lapatinib in mice with brain metastasis at 0.5, 1, 2, 4, and 8 h after administration of Tykerb (p.o. 100 mg/kg), LS (i.v. 10 mg/kg) or LHNPs (i.v. 10 mg/kg) and in normal mice after administration of LS and LHNPs (n = 4).