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. 2016 Apr 20;7(23):34356–34370. doi: 10.18632/oncotarget.8879

Figure 5. The changes of function in gastric cancer cells when AEP was knocked-down or overexpressive.

Figure 5

A. The change in cell migration in response to AEP overexpression or knockdown as evidenced by the scratch method. The migratory ability decreased in response to AEP inhibition and vice versa. B. The change in invasiveness as evidenced by the transwell method. The invasive ability decreased in response to AEP inhibition and vice versa. C. The change of cancerous nodes in peritoneal cavity in response to AEP knockdown and overexpression in nude mice. AEP inhibition decreased the number and the weight of tumor nodules in peritoneal cavity, and vice versa. The comparison of the weight and the number of cancerous nodes in peritoneal cavity was also shown in this figure. D. The cell cycle arrested at G1 stage if AEP was knocked down. The population of sub-G1 cells significantly increased. E. After PI staining, the percent of apoptotic cells increased when AEP was knocked-down. *P<0.05, **P<0.01. (GFP-NC: control of empty vector; AEP-OE: AEP-overexpression; NC: negatively control; AEP-KD1: AEP-knocking down 1; AEP-KD2: AEP-knocking down 2)