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. 2016 Apr 30;7(23):34430–34441. doi: 10.18632/oncotarget.9119

Figure 5. The role of AT101 in the treatment of Her-2 positive gastric cancer with 5-FU based therapy in vivo.

Figure 5

(A) Kaplan-Meier plot of 75 patients with Her-2 positive gastric cancer following 5-FU treatment showing low APE1 (n = 32) expression associated with shorter overall survival. (B) Kaplan-Meier plot of 75 patients with Her-2 positive gastric cancer following 5-FU treatment showing low APE1 (n = 39) expression associated with poorer relapse free survival. (C) and (D) The tumor weight and volume of xenograft mice model in 5-FU sequential treatment with AT101 became smaller than those with 5-FU treatment alone. (E) The downregulated of BCL-2 and Bcl-XL and increased caspase 3 expression were shown in a subset of tumors after 5-FU and 5-FU sequential AT101 treatment.