Figure 6. FXR agonist markedly sensitizes the tumor xenografts formed by GBC-SD cells to CDDP cytotoxicity without displaying obvious systemic toxicity in vivo.

The tumor-bearing mice were injected intraperitoneally with dissolvent, 30 mg/kg GW4064 alone, 2 mg/kg CDDP alone and CDDP/GW4064 coadministration (n=8/group). A. Photograph of transplanted tumors after the mice were exposed to treatments. B. Average weight of transplanted tumors after the mice were exposed to treatments. *P <0.05, combination treatment group compared with CDDP-alone group. C. Average body weight of tumor-bearing mice. D. Histology of livers, kidneys and hearts of tumor-bearing mice. Scale bar: 30μm.