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. 2016 Apr 25;7(23):34630–34642. doi: 10.18632/oncotarget.8969

Figure 3. S100A4 is overexpressed in lung adenocarcinoma, where it associates with decreased overall survival.

Figure 3

A-D. Using semi-quantitative IHC data from our TMA, we found that S100A4 levels were significantly elevated in adenocarcinoma (ADC) when compared to squamous cell carcinoma (SCC, A), which was confirmed using an external gene expression dataset (B). In patients with lung adenocarcinoma, elevated expression of S100A4 (>2.5) correlated with shorter median survival (C). A significant relationship between elevated S100A4 expression and overall survival was not identified when examining all histologic subtypes (NSCLC) combined (D).