Table 2. Adverse events of the included studies.

Adverse events	All grades			Grades 3–4
	OR (95% CI)	p value	I2	OR (95% CI)	p value	I2
Neutropenia [7, 9–11]	0.63 (0.40, 0.99)	0.04‡	76%	0.50 (0.35, 0.71)	0.001‡	62%
Febrile neutropenia [7, 11]	0.55 (0.21, 1.39)	0.21	80%	0.59 (0.24, 1.45)	0.25	73%
Leukopenia [7, 9, 10]	0.69 (0.43, 1.11)	0.12	55%	0.34 (0.15, 0.78)	0.01‡	62%
Thrombocytopenia [7, 9–11]	1.29 (1.04, 1.61)	0.02‡	0%	0.99 (0.69, 1.42)	0.95	0%
Anemia [7, 9–11]	0.50 (0.41, 0.61)	< 0.0001‡	47%	0.47 (0.36, 0.62)	< 0.0001‡	36%
Nausea [7, 10]	0.65 (0.50, 0.86)	0.003‡	30%	0.78 (0.41, 1.47)	0.44	5%
Vomiting [7, 10]	0.66 (0.29, 1.50)	0.32	85%	0.42 (0.14, 1.22)	0.11	0%
Diarrhea [7, 9–12]	0.83 (0.68, 1.01)	0.06	32%	1.25 (0.90, 1.73)	0.19	25%
Stomatitis [7, 9–12]	0.79 (0.66, 0.96)	0.02‡	0%	1.52 (0.80, 2.87)	0.20	0%
Fatigue [7, 9, 10]	0.74 (0.45, 1.24)	0.25	54%	0.93 (0.39, 2.22)	0.87	52%
Alopecia [9–12]	0.68 (0.45, 1.03)	0.07	51%	0.46 (0.35, 0.60)	< 0.0001‡	0%
Neurosensory toxicity [7, 9–12]	8.68 (5.28, 14.27)	< 0.0001‡	78%	8.37 (3.99, 17.59)	< 0.0001‡	32%
Creatinine [7, 9]	0.24 (0.07, 0.77)	0.02‡	68%	0.16 (0.02, 1.36)	0.09	NA
Thromboembolism [10, 11]	0.42 (0.28, 0.64)	< 0.0001‡	10%	NA	NA	NA

CI: confidence interval, NA: not assessable, ‡: p < 0.05: the difference is significant.