Skip to main content
. 2016 Apr 26;7(23):34956–34976. doi: 10.18632/oncotarget.9008

Figure 8. Specific cell cycle events associated with either DNA re-replication or unscheduled endoreplication.

Figure 8

The 42 genes in Table 1 participate in one or more of eight cell cycle events that restrict genome duplication to once per cell division. FACS analyses of HCT116 cells (±ZVAD) transfected with the indicated siRNA (Supplementary Figure S2) revealed that some cell cycle events (indicated in red) prevented primarily endoreplication whereas others prevented primarily DNA re-replication (indicated in blue). See text for details. Origin licensing refers to the assembly of prereplication complexes during the anaphase to G1 phase transition. Origin activation refers to the assembly of initiation complexes during the G1 to S phase transition.