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. 2016 May 7;7(23):34988–35000. doi: 10.18632/oncotarget.9222

Figure 3. Impact of oprozomib in monotherapy or in combination with ER stress modulators on an orthotopic and a xenograft model for HCC.

Figure 3

(A) Photographs of representative livers after different treatments. (B) Reticulin staining. Scale bar: 100 μm. (C) Assessment of tumor burden in the carcinogen-induced mouse model in randomly selected high-power fields. (D) Hepatic caspase-3/7 activity ex vivo. Values represent the mean ± SD. (E) Real-time PCR analysis and (F) Immunoblotting of UPR targets in isolated DEN-induced tumors following the indicated treatments. Densitometric analysis relative to tubulin is indicated below. *p < 0.05, **p < 0.01, ***p < 0.001.