Table 5. Uni- and multi-variate logistic analysis of clinicopathologic factors for pCR.
| Variables | Univariate | Multivariate | |||
|---|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | ||
| Age (year) | |||||
| ≤56 vs >56 | 1.129 (0.430-2.960) | 0.806 | — | — | |
| Gender | |||||
| Male vs female | 0.743 (0.253-2.186) | 0.590 | — | — | |
| Hg (g/L) | |||||
| ≤110 vs >110 | 4.490 (0.541-37.27) | 0.164 | — | — | |
| Tumor location (cm) | |||||
| ≤5.0 vs >5.0 | 0.762 (0.285-2.033) | 0.587 | — | — | |
| CEA level ( ng/ml) | |||||
| <5.00 vs ≥5.00 | 0.378 (0.124-1.155) | 0.088 | 0.300 (0.089-1.012) | 0.052 | |
| Histologic grade | |||||
| G1-2 vs G3 | 0.983 (0.306-3.156) | 0.977 | — | — | |
| APAF-1expression | |||||
| low vs high | 2.931 (1.014-8.473) | 0.047 | 4.291 (1.342-13.699) | 0.014 | |
| COX-2 expression | |||||
| low vs high | 0.287 (0.094-0.876) | 0.028 | 0.205 (0.059-0.708) | 0.012 | |
| Interval between completion of RT and surgery (weeks)# | |||||
| ≤7 vs >7 | 0.695 (0.263-1.833) | 0.462 | — | — | |
HR: hazard ratio; CI: confidence interval;
#
interval between neo-CRT and surgery