Table 2. Univariable Cox proportional hazards regression analyses of cell cycle progression (CCP) score, molecular prognostic score (mPS), and clinical characteristics with 5-year lung cancer mortality in the evaluable analysis set.
| Variable | Hazard ratio (95% CI) | P value |
|---|---|---|
| CCP score | 2.46 (1.85, 3.29) | <0.001 |
| mPS | 2.67 (2.08, 3.42) | <0.001 |
| Age at diagnosis | 1.03 (1.01, 1.06) | 0.003 |
| Sex | 0.065 | |
| Male | 1 | |
| Female | 0.68 (0.45, 1.03) | |
| Smoking status | 0.109 | |
| Never | 1 | |
| Former | 1.94 (1.02, 4.17) | |
| Current | 2.06 (0.92, 4.91) | |
| Surgical procedure | <0.001 | |
| Pneumonectomy/bilobectomy/lobectomy | 1 | |
| Segmentectomy | 2.11 (1.07, 3.81) | |
| Wedge resection | 2.79 (1.74, 4.38) | |
| Tumor size | 1.56 (1.29, 1.87) | <0.001 |
| Pathological stage | <0.001 | |
| IA | 1 | |
| IB | 3.65 (2.43, 5.53) | |
| Pleural invasion | <0.001 | |
| PLX/PL0 | 1 | |
| PL1 | 3.29 (2.06, 5.14) | |
| PL2 | 6.12 (2.36, 13.05) | |
| Lymphatic invasion | <0.001 | |
| Absent | 1 | |
| Present | 3.32 (2.20, 5.06) | |
| Vascular invasion | <0.001 | |
| Absent | 1 | |
| Present | 3.16 (2.09, 4.76) | |
| Morphological grade | <0.001 | |
| Low | 1 | |
| Intermediate | 5.74 (1.78, 35.11) | |
| High | 13.41 (4.13, 82.37) |
Note. Hazard ratios for CCP score and mPS are per the interquartile range of each score variable, respectively.
CI = confidence interval.