Table 3. Multivariable Cox proportional hazards regression analysis of cell cycle progression (CCP) score, molecular prognostic score (mPS), and clinical characteristics with 5-year lung cancer mortality in the evaluable analysis set.
| Variable | Analysis with CCP score | Analysis with mPS | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |
| CCP score | 1.60 (1.14, 2.24) | 0.006 | ||
| mPS | 1.77 (1.18, 2.66) | 0.006 | ||
| Age at diagnosis | 1.03 (1.01, 1.05) | 0.016 | 1.03 (1.01, 1.05) | 0.016 |
| Sex | 0.343 | 0.342 | ||
| Male | 1 | 1 | ||
| Female | 0.82 (0.54, 1.25) | 0.82 (0.54, 1.24) | ||
| Smoking status | 0.676 | 0.675 | ||
| Never | 1 | 1 | ||
| Former | 1.35 (0.69, 2.95) | 1.35 (0.69, 2.95) | ||
| Current | 1.41 (0.60, 3.51) | 1.41 (0.60, 3.51) | ||
| Surgical procedure | <0.001 | <0.001 | ||
| Pneumonectomy/Bilobectomy/Lobectomy | 1 | 1 | ||
| Segmentectomy | 3.31 (1.62, 6.30) | 3.31 (1.62, 6.30) | ||
| Wedge resection | 4.65 (2.71, 7.91) | 4.65 (2.71, 7.90) | ||
| Tumor size | 1.64 (1.24, 2.14) | <0.001 | 1.64 (1.24, 2.15) | <0.001 |
| Pathological stage | 0.720 | 0.158 | ||
| IA | 1 | 1 | ||
| IB | 0.87 (0.39, 1.90) | 0.53 (0.22, 1.28) | ||
| Pleural invasion | 0.056 | 0.057 | ||
| PLX/PL0 | 1 | 1 | ||
| PL1 | 1.94 (0.91, 4.12) | 1.94 (0.91, 4.12) | ||
| PL2 | 3.39 (1.15, 8.79) | 3.38 (1.15, 8.76) | ||
| Lymphatic invasion | 0.020 | 0.019 | ||
| Absent | 1 | 1 | ||
| Present | 1.73 (1.09, 2.77) | 1.74 (1.10, 2.78) | ||
| Vascular invasion | 0.089 | 0.091 | ||
| Absent | 1 | 1 | ||
| Present | 1.52 (0.94, 2.44) | 1.51 (0.94, 2.44) | ||
| Morphological grade | 0.012 | 0.011 | ||
| Low | 1 | 1 | ||
| Intermediate | 3.08 (0.92, 19.13) | 3.08 (0.92, 19.13) | ||
| High | 5.09 (1.46, 32.18) | 5.10 (1.46, 32.22) | ||
Note. Hazard ratios for CCP score and mPS are per the interquartile range of each score variable, respectively.
CI = confidence interval.