Table 4. Univariable Cox proportional hazards regression analyses of cell cycle progression (CCP) score, molecular prognostic score (mPS), and clinical characteristics with overall survival in the evaluable analysis set.
| Variable | Hazard ratio (95% CI) | P value |
|---|---|---|
| CCP score | 1.73 (1.41, 2.11) | <0.001 |
| mPS | 1.88 (1.58, 2.23) | <0.001 |
| Age at diagnosis | 1.05 (1.03, 1.07) | <0.001 |
| Sex | <0.001 | |
| Male | 1 | |
| Female | 0.61 (0.46, 0.81) | |
| Smoking status | 0.190 | |
| Never | 1 | |
| Former | 1.44 (0.96, 2.26) | |
| Current | 1.48 (0.87, 2.53) | |
| Surgical procedure | <0.001 | |
| Pneumonectomy/bilobectomy/lobectomy | 1 | |
| Segmentectomy | 1.62 (1.00, 2.49) | |
| Wedge resection | 2.08 (1.48, 2.86) | |
| Tumor size | 1.37 (1.19, 1.56) | <0.001 |
| Pathological stage | <0.001 | |
| IA | 1 | |
| IB | 2.44 (1.83, 3.23) | |
| Pleural invasion | <0.001 | |
| PLX/PL0 | 1 | |
| PL1 | 2.71 (1.95, 3.70) | |
| PL2 | 3.06 (1.30, 6.07) | |
| Lymphatic invasion | <0.001 | |
| Absent | 1 | |
| Present | 2.15 (1.62, 2.84) | |
| Vascular invasion | <0.001 | |
| Absent | 1 | |
| Present | 2.31 (1.74, 3.06) | |
| Morphological grade | <0.001 | |
| Low | 1 | |
| Intermediate | 1.95 (1.16, 3.55) | |
| High | 3.01 (1.74, 5.59) |
Note. Hazard ratios for CCP score and mPS are per the interquartile range of each score variable, respectively.
CI = confidence interval.