Table 1. The main features of enrolled studies.
Author | Year | Population | Sample size | Method | Cut-off | miRNA | Survival analysis | Source of HR | Follow-up (month) |
---|---|---|---|---|---|---|---|---|---|
Luo | 2015 | China | 88 | qRT-PCR | Median | miR-26b | OS, RFS | Reported | mean 74 (5.12-98.5) |
Safari | 2015 | Iran | 40 | qRT-PCR | Median | miR-20a | OS | DE | 100 |
miR-10a | OS | DE | |||||||
Wang C | 2015 | China | 138 | qRT-PCR | Median | miR-335 | OS, RFS | Reported, DE | Mean 71(23-117) |
Wang Q | 2015 | China | 114 | qRT-PCR | Median | miR-145 | OS | Reported | median 47(11-69) |
He | 2014 | China | 73 | qRT-PCR | ROC curve | miR-107 | OS, DFS | DE | median 68.4 |
miR-130a | OS, DFS | DE | |||||||
Liang | 2014 | China | 335 | qRT-PCR | X-tile algorithm | miR-215 | DFS | Reported | 60 |
Ma | 2014 | China | 60 | qRT-PCR | ROC curve | miR-205 | OS | Reported | 60 |
Park | 2014 | Korea | 45 | qRT-PCR | 2.5-fold | miR-363-3p | OS | Reported | 60 |
Wang | 2014 | China | 54 | qRT-PCR | Median | miR-31 | OS | Reported | 60 |
Yang | 2014 | China | 133 | qRT-PCR | Median | miR-126 | OS | Reported | 60 |
Luo | 2013 | China | 60 | qRT-PCR | Mean | miR-497 | OS, DFS | Reported, DE | 60 |
Shen | 2013 | China | 126 | qRT-PCR | Median | miR-224 | OS | DE | median 51.9 |
Huang | 2012 | China | 44 | qRT-PCR | Mean | miR-125b | OS | Reported | mean 23.6 (2-70) |
miR-100 | OS | Reported | |||||||
miR-143 | OS | DE | |||||||
miR-145 | OS | DE | |||||||
miR-199a-5p | OS | DE |
HR: hazard ratio; qRT-PCR: quantitative real-time polymerase chain reaction; OS: overall survival; RFS: recurrence-free survival; DFS: disease-free survival.