Table 5. Multivariate analysis of preoperative serum tumor makers with clinicopathological traits in the training and the validation cohorts.

	CA125 (+)		CA19-9 (+)		CEA (+)
	OR (95%CI)	P	OR (95%CI)	P	OR (95%CI)	P
Training cohort
Gender	1.614 (1.231-2.115)	0.001	1.650 (1.184-2.299)	0.003	0.662 (0.461-0.951)	0.026
Age	-	-	1.550 (1.124-2.139)	0.008	-	-
pT stage	1.138 (1.005-1.289)	0.041	1.264 (1.061-1.507)	0.009	1.315 (1.099-1.572)	0.003
pN stage	1.197 (1.077-1.331)	0.001	1.345 (1.180-1.532)	<0.001	1.277 (1.120-1.456)	<0.001
Validation cohort
Gender	1.538 (1.101-2.148)	0.012	-		0.372 (0.229-0.603)	<0.001
Tumor size	1.596 (1.310-1.945)	<0.001	-		-
Macroscopic type	-		-		1.279 (1.036-1.580)	0.022
pT stage	-		1.289 (1.043-1.592)	0.019	-
pN stage	-		1.288 (1.106-1.501)	0.001	1.194 (1.029-1.385)	0.019

OR = odds ratio; CI = confidence interval.