Table 1. General characteristics of 1134 gastric cancer patients associated with overall survival.

	No. of patients(%)	OS (months) mean(95% CI)	P-valuea
Age (<60 / ≥60 years)	650 (57.3%) / 484 (42.7%)	103.8 (96.5, 111.1) / 76.5 (67.6, 85.4)	<0.001
Sex (Male / Female)	770 (67.9%) / 364 (32.1%)	91.6 (84.6, 98.6) / 95.5 (85.6, 105.4)	0.987
Tumor location	254 (22.4%) / 223 (19.7%)/	65.2 (57.0, 73.4) / 60.5 (48.3, 72.6) /	<0.001
(Upper / Middle / Lower third)	657 (57.9%)	105.9 (98.5, 113.3)
Tumor size	129 (11.4%) / 450 (39.7%)/	130.9 (120.0, 141.7) / 98.5 (90.2, 106.7) /	<0.001
(<3 / 3≤ diameter <5 / ≥5)	555 (48.9%)	76.2 (68.1, 84.2)
Histological grade	218 (19.2%) / 916 (80.8%)	100.9 (90.3, 111.5) / 89.3 (82.5, 96.1)	0.009
(Well / Poorly differentiated)
Depth of invasion	220 (19.4%) / 92 (8.1%)/	122.9 (112.5, 133.2) / 117.8 (100.7, 135.0) /	<0.001
(T1 / T2 / T3 / T4)	277 (24.4%) / 545 (48.1%)	86.0 (75.0, 97.0) / 64.4 (59.1, 69.7)
Nodal status	370 (32.6%) / 176 (15.5%)/	122.7 (112.7, 132.7) / 106.5 (94.8, 118.2) /	<0.001
(N0 / N1 / N2 / N3)	207 (18.3%) / 381 (33.6%)	83.8 (71.7, 95.9) / 56.0 (48.2, 63.9)	<0.001
TNM stage (I / II / III)	232 (20.5%) / 290 (25.6%)/	141.2 (131.6, 150.8) / 106.0 (94.9, 117.2) /	<0.001
	612 (54.0%)	68.9 (61.8, 76.1)
CEA (Normal / Elevated)	883 (77.9%) / 251 (22.1%)	106.0 (99.5, 112.5) / 54.6 (46.1, 63.1)	<0.001
CA72-4 (Normal / Elevated)	896 (79.0%) / 238 (21.0%)	101.2 (95.0, 107.5) / 64.6 (53.4, 75.8)	<0.001
CA19-9 (Normal / Elevated)	930 (82.0%) / 204 (18.0%)	99.7 (93.4, 106.1) / 56.9 (48.1, 65.6)	<0.001
CTM (0 / 1 / 2)	632 (55.7%) / 340 (30.0%)/	115.4 (108.1, 122.7) / 74.1 (63.8, 84.4)/	<0.001
	162 (14.3%)	52.0 (41.8, 62.2)

Abbreviations: OS = overall survival; CI = confidence interval; TNM = tumor-node-metastasis staging; CEA = carcinoembryonic antigen; CA = carbohydrate antigen; CTM = the combination of preoperative tumor markers;

^aKaplan–Meier survival analysis.