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. 2016 Mar 3;4:1–14. doi: 10.2147/HP.S101133

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© 2016 D’Hulst et al. This work is published and licensed by Dove Medical Press Limited

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Effect of chronic hypoxia on key markers of proteolytic pathways.

Notes: (A) LC3b-II/I ratio, (B) LC3b-II and (C) LC3b-I protein content, (D) LC3b mRNA content, (E) P62 protein content, (F) P62 mRNA content, (G) Gabarapl1 and (H) Cathepsin L mRNA content, (I) phospho-FoxO1/3a, (J) MAFbx, (K) Psmb1, and (L) MuRF-1 mRNA content in human skeletal muscle before (PRE) and after (POST) 15 days of exposure to environmental hypoxia. (M) Representative blots. Dashed lines are individual values, and solid lines are mean ± SEM (n=8). *P<0.05 vs PRE.

Abbreviations: FoxO1/3a, forkhead box 1/forkhead box O3a; Gabarapl1, gamma-aminobutyric acid receptor-associated protein-like 1; LC3b, microtubule-associated protein 1 light chain 3; MAFbx, muscle atrophy F box; MuRF-1, muscle RING-finger protein-1; Psmb1, proteasome subunit beta type 1; SEM, standard error of mean.