Table 1.
Main clinicopathological traits and TOP2A expression in 145 patients with TNBC
| Items | Number (%) | TOP2A-QD, median (IQR) | P-value | TOP2A-IHC, median (IQR) | P-value |
|---|---|---|---|---|---|
| Age (years) | 0.188a | 0.379a | |||
| ≤50 | 91 (62.76) | 45.0 (28.0–67.0) | 0.45 (0.32–0.60) | ||
| >50 | 54 (37.24) | 37.5 (22.5–74.5) | 0.40 (0.28–0.65) | ||
| Tumor size (cm) | 0.002b | 0.005b | |||
| T1 (T≤2) | 98 (67.59) | 34.5 (23.0–64.0) | 0.39 (0.288–0.580) | ||
| T2 (2<T≤5) | 41 (28.28) | 46.0 (32.5–72.0) | 0.490 (0.355–0.61) | ||
| T3 (T>5) | 6 (4.13) | 88.0 (49.0–89.3) | 0.715 (0.528–0.875) | ||
| Lymph node status | <0.001a | <0.001a | |||
| Negative | 74 (51.03) | 27.0 (21.0–45.0) | 0.33 (0.24–0.49) | ||
| Positive | 71 (48.97) | 62.0 (41.0–84.0) | 0.54 (0.41–0.71) | ||
| Tumor grade | 0.005b | 0.034b | |||
| Grade 1 | 8 (5.52) | 43.0 (21.8–86.5) | 0.405 (0.215–0.873) | ||
| Grade 2 | 116 (80) | 36.5 (24.3–65.0) | 0.410 (0.290–0.575) | ||
| Grade 3 | 21 (14.48) | 56.0 (44.5–71.0) | 0.540 (0.455–0.685) |
Notes:
a
Mann–Whitney U-test.
b
Kruskal–Wallis H-test.
Abbreviations: TOP2A, topoisomerase 2 alpha; QD, quantum dot; TNBC, triple-negative breast cancer; IQR, interquartile range; IHC, immunohistochemistry.