Table 1.
Characteristics of wild-type and Epo-TAgh male mice in normoxic conditions
References | Wild-type mice | Epo-TAgh mice | ||
---|---|---|---|---|
Hemoglobin (g·dL−1)b | Macarlupu et al81 | 17.1±0.3 | 6.9±0.3a | |
Hematocrit (%)b | Macarlupu et al81 | 54.2±0.8 | 24.0±1.6a | |
Cardiac characteristics | Heart rate (bpm)c | El Hasnaoui-Saadani et al20 | 500±27 | 548±46 |
Stroke volume (μL·g−1)c | El Hasnaoui-Saadani et al20 | 1.9±0.19 | 3.2±0.68a | |
Cardiac output (mL·min−1·g−1)c | El Hasnaoui-Saadani et al20 | 0.94±0.14 | 1.76±0.43a | |
Systolic blood pressure (mmHg)c | El Hasnaoui-Saadani et al20 | 96.7±8.5 | 94.2±5.8 | |
Right ventricular weight (mg)b | Macarlupu et al82 | 23±1 | 33±2a | |
Left ventricular and septum weight (mg)b | Macarlupu et al82 | 80±2 | 113±3a | |
Fulton ratiob | Macarlupu et al82 | 0.288±0.013 | 0.297±0.010a | |
Ventilatory parameters | Minute ventilation (mL·min−1·g−1)c | Voituron et al90 | 2.26±0.48 | 2.17±0.53 |
Respiratory frequency (c·min−1)c | Voituron et al90 | 261±34 | 284±54 | |
Tidal volume (μL·g−1)c | Voituron et al90 | 8.63±1.26 | 7.62±1.09 | |
Resting oxygen consumption (mL·min−1·kg−1)b | Macarlupu et al81 | 93.3±4.7 | 96.8±6.5 | |
Maximal oxygen consumption (mL·min−1·kg−1)b | Macarlupu et al81 | 270.7±22.0 | 210.2±12.3a |
Note:
Indicates significant difference between wild-type and Epo-TAgh mice.
Data presented as mean ± SEM.
Data presented as mean ± SD.
Abbreviations: Epo, erythropoietin; Epo-TAgh mice, Epo-deficient mice; SD, standard deviation; SEM, standard error of the mean.