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. 2016 Nov 3;1(18):e89590. doi: 10.1172/jci.insight.89590

Figure 3. Calpastatin overexpression in β cells protects hTG mice from diabetes.

Figure 3

(A) Weekly fasting blood glucose (n = 4–9 per time point) and (B) frequency of diabetes in hTG and hTG:hCAST mice. (C) Fasting blood glucose and (D) β cell mass were measured in 12-week-old mice; WT (n = 5), WT:hCAST (n = 5), hTG (n = 6), and hTG:hCAST (n = 6). (E) β Cell apoptosis was assessed by TUNEL and (F) β cell proliferation was assessed by Ki67 immunofluorescence staining in 12-week-old mice; WT (n = 3), WT:hCAST (n = 3), hTG (n = 6), and hTG:hCAST (n = 6). Data are expressed as mean ± SEM; *P < 0.05, ***P < 0.001 vs. hTG; ##P < 0.01, ###P < 0.001 vs. WT; 1-way ANOVA followed by Fisher’s LSD post-hoc test.