Table 7.
Associations between NSCLC risk and SNPs by smoking status.
| Genotype | Non-Smoker | Smoker | ||||
|---|---|---|---|---|---|---|
| Cases (%) | Controls (%) | OR a (95% CI) | Cases (%) | Controls (%) | OR a (95% CI) | |
| CYP24A1 (rs2181874) | ||||||
| GG + GA | 102 (80.3%) | 215 (94.7%) | 1.00 (ref) | 256 (86.2%) | 197 (92.1%) | 1.00 (ref) |
| AA | 25 (19.7%) | 12 (5.3%) | 2.14 (1.47–3.43) | 41 (13.8%) | 17 (7.9%) | 3.57 (2.66–4.74) |
| p | 0.031 | 0.019 | ||||
| p-Interaction | 0.016 | |||||
| CYP24A1 (rs6068816) | ||||||
| CC + CT | 91 (71.7%) | 158 (74.0%) | 1.00 (ref) | 282 (94.9%) | 182 (85.1%) | 1.00 (ref) |
| TT | 36 (28.3%) | 69 (30.4%) | 0.84 (0.65–1.41) | 15 (5.1%) | 32 (14.9%) | 0.43 (0.27–1.02) |
| p | 0.079 | 0.006 | ||||
| p-Interaction | 0.038 | |||||
| VDR (rs10735810) | ||||||
| CC + CT | 112 (88.2%) | 198 (87.2%) | 1.00 (ref) | 237 (79.8%) | 186 (86.9%) | 1.00 (ref) |
| TT | 15 (11.8%) | 29 (12.8%) | 1.16 (0.82–1.34) | 60 (20.2%) | 28 (13.1%) | 1.93 (1.41–2.76) |
| p | 0.256 | 0.015 | ||||
| p-Interaction | 0.004 | |||||
| VDR (rs1544410) | ||||||
| GG + GA | 116 (91.3%) | 172 (75.8%) | 1.00 (ref) | 294 (98.9%) | 175 (81.8%) | 1.00 (ref) |
| AA | 11 (8.7%) | 55 (24.2%) | 0.51 (0.34–1.17) | 3 (1.0%) | 39 (18.2%) | 0.26 (0.20–0.69) |
| p | 0.002 | 0.001 | ||||
| p-Interaction | 0.002 | |||||
a Covariates used for adjustment included age, gender, and family history of NSCLC and BMI.