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Crosstalk between EGFR and nuclear factor-κB (NF-κB) signaling pathway. PGE2, prostaglandin E2; IκB, inhibitors of κB; IKK, IκB kinase; COX-2, cyclooxygenase-2; mTOR, mammalian target of rapamycin; Ub, ubiquitylation; PLA2, phosphorlipase A2; P, phosphorylation. Arrows and perpendicular lines indicate activation/induction and inhibition/suppression, respectively.
