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. 2016 Sep 24;17(10):1624. doi: 10.3390/ijms17101624

Figure 1.

Figure 1

Effect of dietary fat on hepatic lipid composition. Wild-type (Pparα+/+) and total Pparα knockout (Pparα−/−) mice fed a standard diet (REF), a diet enriched in n-3 essential fatty acids from fish oil (FISH), an essential fatty acid-deficient (EFAD) diet, or a fat-free (FF) diet ad libitum for 10 weeks were euthanized at ZT14 in the fed state. (a) Determination of the delta body weight gain; (b,c) quantification of hepatic C20:5n-3 eicosapentaenoic acid (b); C18:2n-6 linoleic acid (c); and (d) hierarchical clustering of major hepatic fatty acids quantified by gas chromatography. n = 6–8 mice/genotype/diet. Data represent mean ± SEM. * significant genotype effect, # significant effect of diet composition. ** or ## p ≤ 0.001. REF: standard diet; FISH: diet enriched in n-3 essential fatty acids from fish oil; EFAD: essential fatty acid-deficient diet; FF: fat-free diet.