Table 1.

Serum anti-skin antibodies and cytokine concentrations in patients with inherited epidermolysis and healthy controls.

Parameter	Total n = 80	Controls n = 38	EB Cases n = 42	p-Value	Corrected p-Value *
Anti-skin antibodies, U/mL
DSG1	2.72 (0–38.83)	2.12 (0–15.09)	3.83 (0.18–38.83)	0.005	0.008
DSG3	2.8 (0–40.4)	1.58 (0.08–8.38)	3.72 (0–40.4)	<0.001	<0.001
BP180	3.9 (0–118.8)	1.82 (0–34.41)	7.1 (0.5–118.8)	<0.001	<0.001
BP230	3.55 (0.22–66)	1.68 (0.22–26.74)	4.75 (0.5–66)	<0.001	<0.001
COL7	0.8 (0–41.05)	0.26 (0–3.99)	1.92 (0–41.05)	<0.001	<0.001
Cytokines, pg/mL
IL-1β	5.79 (0.88–192.67)	2.75 (0.88–189.66)	16.62 (1.16–192.67)	<0.001	<0.001
IL-2	61.55 (8.01–3992.66)	31.61 (8.01–2400)	111.23 (18.76–3992.66)	<0.001	<0.001
IL-4	0.96 (0.79–4.5)	0.95 (0.8–2.07)	0.96 (0.79–4.5)	0.319	0.342
IL-6	15.12 (4.46–1000)	8.54 (4.46–1000)	33.44 (5.32–1000)	<0.001	<0.001
IL-8	39.92 (12.96–939.06)	27.96 (12.96–939.06)	45.09 (13.14–449)	0.171	0.197
IL-10	28.88 (5.86–250)	21.12 (5.86–250)	32.98 (8–250)	0.006	0.008
IL-12	1.46 (1–9.21)	1.36 (1–7.29)	1.52 (1.14–9.21)	0.045	0.056
TNF-α	176.1 (128.17–4800)	176.1 (128.17–1351.09)	175.12 (137.66–4800)	0.385	0.385
TNF-β	1538.24 (802.84–36,000)	1267.11 (802.84–3764.79)	1737.07 (1101.8–36,000)	<0.001	<0.001
IFN-γ	220.68 (73.56–5000)	176.34 (73.56–910)	330.16 (79.18–5000)	0.001	0.002

BP180: antibodies against bullous pemphigoid 180; BP230: antibodies against bullous pemphigoid 230; COL7: type VII collagen; DSG1: antibodies against desmoglein 1; DSG3: antibodies against desmoglein 3; EB: inherited epidermolysis bullosa; IFN: interferon; IL: interleukin; TNF: tumor necrosis factor. Median values (range in parentheses). * p-Values were adjusted for multiple testing using the false discovery rate method (with the Benjamini-Hochberg procedure).